Project: Cancer Immunotherapy
Analyzing change in metabolic homeostasis and cytokine signalling during immune-tumour cell interactions and generation of anti-tumour immune response using adjuvant coated therapy along with limiting the immune regressive signals Introduction Tumor cells evade immune response by taking advantage of peripheral tolerance. Peripheral tolerance is the downregulation of T-cell priming and getting rid of auto-reactive T-cells at the lymphatic system and tissue site. T-cell priming is the activation of T-cells in response to foreign antigens and to generate an immune response against it. In this process, the T-cell receptor (TCR) binds to the antigen displayed in MHC on the surface of antigen-presenting cells. Sufficient binding of co-stimulatory molecules such as CD80 and CD86 (B7 family) present on APC binds to CD28 on T-cells to upregulate proliferation and increase survival of T-cells (10). Immune checkpoints such as CTLA-4 and PD-1 help...